Copper(II) Binding to α-Synuclein, the Parkinson’s Protein
نویسندگان
چکیده
Variations in tryptophan fluorescence intensities confirm that copper(II) interacts with alpha-synuclein, a protein implicated in Parkinson's disease. Trp4 fluorescence decay kinetics measured for the F4W protein show that Cu(II) binds tightly (Kd 100 nM) near the N-terminus at pH 7. Work on a F4W/H50S mutant indicates that a histidine imidazole is not a ligand in this high-affinity site.
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عنوان ژورنال:
دوره 130 شماره
صفحات -
تاریخ انتشار 2008